2019 Best Tech Startups in San Diego

The Tech Tribune staff has compiled the very best tech startups in San Diego, California. In doing our research, we considered several factors including but not limited to:

  1. Revenue potential
  2. Leadership team
  3. Brand/product traction
  4. Competitive landscape

Additionally, all companies must be independent (unacquired), privately owned, at most 10 years old, and have received at least one round of funding in order to qualify.

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1. Human Longevity

Human Longevity

Founded: 2013

“Human Longevity, Inc. ™ (HLI) is the genomics-based, health intelligence company creating the world’s largest and most comprehensive database of whole genome, phenotype and clinical data. HLI is developing and applying large scale computing and machine learning to make novel discoveries from these data to generate personalized health insights. Our goal is to extend healthy human life by revolutionizing human health and transforming the practice of medicine.

Our DNA determines so much about each of us, but other factors can also influence our health.”

2. Brain Corporation

brain corporation

Founded: 2009

Also honored in: 2018 Best Tech Startups in San Diego

“Brain Corp is a software technology company specializing in the development of intelligent, autonomous systems. Brain Corp’s A.I. technology represents the next generation of artificial brains for self-driving vehicles (SDVs). We’re building brains for robots, and turning today’s manually-operated machines into tomorrow’s autonomous solutions.”

3. Tealium


Founded: 2008

Also honored in: 2018 Best Tech Startups in San Diego

“Tealium revolutionizes today’s digital businesses with a universal approach to managing the ever-increasing flows of customer data – spanning web, mobile, offline and Internet of Things devices. With the power to unify customer data into a single source of truth, combined with a turnkey integration ecosystem supporting more than 1,000 vendors and technologies, Tealium’s Universal Data Hub enables organizations to leverage real-time data to create richer, more personalized digital experiences across every channel.”

4. Seismic


Founded: 2010

Also honored in: 2018 Best Tech Startups in San Diego

“Seismic is the leading global marketing and sales enablement solution, improving close rates and delivering larger deals for sales while increasing marketing’s impact on the bottom line. Large enterprises use Seismic to increase sales productivity through the automatic distribution of relevant information and personalized content to reps for any buyer interaction. Powerful content controls and visibility into usage ensures brand integrity and reduces risk. Seismic’s machine learning and analytics capabilities continuously improves the entire enablement process for large enterprises, increasing the ROI of sales content and tying it directly to revenue.”

5. Empyr


Founded: 2011

“Empyr is a card-linked online-to-offline (O2O) commerce platform that generates serious revenue for websites and apps while rewarding their users with cash back at local merchants.

Websites and apps use Empyr’s API or private-label solution to display offline offers, such as 10% cash back at a local restaurant or retail store. Consumers earn cash back simply by linking any debit or credit card and using it to pay at the store, eliminating the need for coupons or vouchers. The website or app where the consumer linked their card earns revenue from the offline purchase, and the merchant is able to attribute actual sales to a specific website or app.”

6. Reflexion Health

Reflexion Health

Founded: 2012

“Our mission is to transform healthcare delivery and redesign patient care, exploiting appropriate technology to educate, motivate, measure, manage, and report – all to ease the patient’s journey, amplify the clinician’s impact, and speed recovery.

We believe that by doing this well, we can better manage critical resources, improve clinical outcomes and delight patients and clinicians.”

7. Kai Technologies

Kai Technologies

Founded: 2016

“KaiOS Technologies powers an emerging ecosystem of affordable digital products and services. Our flagship product, KaiOS, is a web-based operating system that enables a new category of smart feature phones and other IoT devices that require limited memory, while still offering a rich user experience. Our mission is to help bridge the digital divide—connecting the billions of people in emerging markets who still don’t have internet access, as well as those in established markets who are looking for easy-to-use phones with advanced functionality.”


Founded: 2013

“ is a mobile-first, socially-focused suite of cloud-based applications that provides an ideal solution for event organizers and event goers alike. Organizers benefit from a dashboard that features the necessary tools to manage, market and monetize their events—including detailed analytics, robust reporting with actionable insights, integrated marketing and outreach tools, enhanced payment options, and comprehensive functionality to create interactive communities and affinity around their brands. Event goers get access and inspiration via the site—a place to explore experiences based on interests, discover aggregated social content and share the experiences that matter most to them.”

9. DB CyberTech

DB Networks

Founded: 2009

“Machine Learning Based Predictive Database Data Loss Prevention — Stops data theft at the source BEFORE it happens.

Information systems are riddled with blind spots. Hackers lurk in the shadows attacking your databases and stealing your most sensitive data. You need DB CyberTech Machine learning based predictive database data loss prevention.

Deep SQL inspection continuously monitors to let you know who’s accessing which databases and what they’re doing. Machine learning is applied to immediately identify insider threats and external database attacks that otherwise would have resulted in your data being stolen.”

10. Cordial


Founded: 2014

“Cordial is a next generation email marketing platform built on real-time data.

We solve the problems that legacy ESP’s create for marketers by simplifying data management and empowering brands to create rich personalized experiences across email and mobile. Using real-time data and machine-learning technology, Cordial creates individual promotional, triggered, transactional, and lifecycle messages, enabling marketers to simplify their processes, accelerate time to value, and make the customer the center of every interaction.”