2021 Best Tech Startups in Cleveland

Powered by CrunchbaseThe Tech Tribune staff has compiled the very best tech startups in Cleveland, Ohio. In doing our research, we considered several factors including but not limited to:

  1. Revenue potential
  2. Leadership team
  3. Brand/product traction
  4. Competitive landscape

Additionally, all companies must be independent (unacquired), privately owned, at most 10 years old, and have received at least one round of funding in order to qualify.

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1. OAREX Capital Markets, Inc.

OAREX Capital Markets, Inc.

Founded: 2013

“Fast flexible funding for digital media companies including viral publishers, app developers/publishers, Supply-Side Platforms, Demand-Side Platforms, and advertising networks and exchanges. We are backed by Arena Investors, LP, a $1B NYC-based global investment firm. Learn more at”

2. Complion


Founded: 2013

Also honored in: 

“Complion is a document management and workflow platform for clinical research sites. Built by clinical researchers for clinical researchers, it transforms the way clinical trial documentation is maintained. Leading physicians, hospitals, academic medical centers, health systems and cancer centers around the country leverage Complion to reduce regulatory burden, improve compliance and streamline operations.

*Complion provides free monthly educational webinars that draw on expertise from our internal team as well as outside leading industry experts. Topics include Clinical Research regulations, policies, and research best practices. For live attendees only, we provide the certificate of attendance and slides so that you can self-report these educational events as continuing research education credits for such professional organizations as the Society of Clinical Research Associates (SoCRA) and the Association of Clinical Research Professionals (ACRP).”

3. Able


Founded: 2014

Also honored in: 

“Able allows recruiters to simplify and automate the onboarding processes that prevent new employees from getting to work, from the most straightforward to the diabolically complex, so they can do what they were hired to do sooner. We that believe that no matter who someone is, what job they do, whether they’re temporary or permanent, every employee can and should be able to have a great first day.”

4. Snip Internet

Snip Internet

Founded: 2016

“Snip Internet is changing residential internet with its “Fat Pipe. Happy Life” mentality. With symmetrical speeds up to 1GBps delivering unmatched upload and download performance, Snip is creating the fastest and most reliable internet experience possible for apartment residents in Cleveland, Detroit, Milwaukee, and Columbus.”

5. CHAMPtitles


Founded: 2018

“Through the application of its secure, patent-pending technology, CHAMPtitles ends the reliance on legacy systems to manage U.S. automobile titles. CHAMPtitles partners with each party in the vehicle title ecosystem to reduce their costs in handling titles, turning the burdensome administrative process of issuing a vehicle title into a profitable activity.”

6. Heureka Software

Heureka Software

Founded: 2014

Also honored in: 

“Over ninety percent of today’s corporations have no idea where their sensitive data is located. Computers and servers are overflowing with information that has been collecting for years. This ever-growing data collection contains valuable and sensitive information such as intellectual property or privacy information making your environment target-rich for data theft.

The Heureka Intelligence Platform gives you real-time access to unstructured data on network file systems, servers, VM’s, laptops and desktops in order to respond to eDiscovery requests, comply with GDPR & privacy regulations and to automate information governance policies.

Not knowing where sensitive data is no longer an option!”

7. Proformex


Founded: 2016

“Twenty-five years of experience in the rapidly changing life insurance industry led the creators of Proformex to the conclusion that agents, fiduciaries, trustees, insureds and policy owners need a way to analyze, monitor and govern InForce policies to track whether the insurance contracts perform as intended.”

8. MedPilot


Founded: 2014

“MedPilot is a leading provider of technology in patient revenue cycle management, designed to help patients, healthcare providers, insurance billing companies, and revenue cycle software vendors. MedPilot’s software uses data science and behavioral targeting to recommend patient engagement methods, personalize communications and resolve outstanding balances. MedPilot also aggregates data to make recommendations to increase the productivity of in-house call centers.”

9. Axuall


Founded: 2018

Also honored in: 2020 Best Tech Startups in Cleveland

“Axuall is a digital network for verifying identity, credentials, and authenticity in real-time. We address a multibillion-dollar need to eliminate waste, prevent fraud, manage risk, and meet the demand for next-generation products and services in healthcare, financial services, manufacturing, government, and other industries where proof matters.

Axuall’s technology digitally fuses assertions with the corresponding digital signatures of authorized verifying entities, forming a cryptographic bond that is continuously re-verified and kept up-to-date. This enables a global network linking credential holders, verifiers, and subscribers, providing self-sovereign, portable, and real-time sharing of digital proof across the expanding marketplace and digital economy.”

10. GenomOncology


Founded: 2012

Also honored in: 2020 Best Tech Startups in Cleveland

“GenomOncology enables the application of genomics in oncology to improve patient care. We have applied our expertise in genomics, technology and data integration to create solutions for cancer care providers. Our solutions are end-to-end: from the data coming out of the sequencer to the bedside where oncologists make treatment decisions. Our technology streamlines workflow and creates actionable reports for pathologists. Downstream, we integrate molecular and clinical information, providing oncologists with powerful decision-support tools that enable treatment selection, patient identification for clinical trials, and a “patients-like-mine”​ feature for use in difficult cases – all delivered through a real-time platform. Our solutions also enable “Big Data”​ analysis of aggregate data to drive research and new insights.”