2022 Best Tech Startups in Greenville (South Carolina)

Powered by CrunchbaseThe Tech Tribune staff has compiled the very best tech startups in Greenville, South Carolina. In doing our research, we considered several factors including but not limited to:

  1. Revenue potential
  2. Leadership team
  3. Brand/product traction
  4. Competitive landscape

Additionally, all companies must be independent (unacquired), privately owned, at most 10 years old, and have received at least one round of funding in order to qualify.

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1. ChartSpan Medical Technologies

ChartSpan Medical Technologies

Founded: 2012

Also honored in:

“ChartSpan is the largest, managed service provider of chronic care management programs in the United States. The company provides turnkey, managed care coordination and compliance programs including MIPS management and Annual Wellness Visit solutions for doctors, clinics, and health systems.

Headquartered in Greenville, SC, ChartSpan manages patient care coordination and value-based programs for more than 100 of the most successful practices and health systems in the United States.”

2. 6AM City

6AM City

Founded: 2016

Also honored in: 2021 Best Tech Startups in South Carolina

“6AM is redefining the future of local media as the fastest growing newsletter-first local media company in the country, delivering the most relevant need-to-know local news and events. We aim to build communities driven by conversation, designed to educate and activate the cities we call home.

6AM City Markets: Greenville, SC (GVLtoday); Columbia, SC (COLAtoday); Charleston, SC (CHStoday); Asheville, NC (AVLtoday); Raleigh, NC (RALtoday); Chattanooga,TN (NOOGAtoday); Nashville, TN (NASHtoday); Lakeland, FL (LALtoday); Louisville, KY (LOUtoday); Lexington, KY (LEXtoday); Columbus, OH (CBUStoday); Kansas City, MO (KCtoday); Richmond, VA (RICtoday); Madison, WI (608today); Indianapolis, IN (INDYtoday); Portland, OR (PDXtoday); Seattle, WA (SEAtoday); Boston, MA (BOStoday); Austin, TX (ATXtoday); Fort Worth, TX (FTWtoday); San Antonio (SATXtoday); San Diego, CA (SDtoday); Sacramento, CA (SACtoday); and San Jose, CA (SJCtoday).”

3. Earnnest


Founded: 2017

“Earnnest is changing the way money moves in real estate. Our digital platform allows buyers to securely and electronically deposit funds directly to an escrow holder. We keep agents, buyers, and escrow holders in the loop with automated emails and tracking information. Say goodbye to lost checks and wire fraud.”

4. Soteria Battery Innovation Group

Soteria Battery Innovation Group

Founded: 2017

“Soteria Battery Innovation Group is dedicated to enabling inherently safe lithium ion batteries through two licensable technologies and an open-innovation platform.

Advanced global companies are implementing heavy and expensive techniques (flame retardants, cooling systems, steel boxes) to contain the potential for thermal runaway, and the damage that occurs when an event happens.

​Even with these advanced techniques, dangerous and costly thermal runaway events can still happen.

The Soteria architecture addresses the root cause of thermal runaway inside lithium-ion cells with thermally stable separators made from advanced fibers and metallized film current collectors that are engineered to stop the flow of current under the giant current densities that lead to lithium battery fires. The architecture provides the same electrical protection as a fuse on the inside of the battery.”

5. Katana Safety

Katana Safety

Founded: 2016

Also honored in: 2021 Best Tech Startups in South Carolina

“The Ultimate Lone Worker Solution. Every day mobile employees provide a wide range of services in increasingly complex environments. Our patented technology connects your employees with trained professionals, helping them navigate vulnerable situations before, during and after they might occur.

The KATANA Safety solution is the world’s first on-demand personal security system that is ALWAYS with you because it attaches directly to your smartphone, ANYONE can use regardless of age and can be taken ANYWHERE, such as classrooms, dorms, workplace or through airport security.

KATANA Safety™ provides three-layers of defense. The KATANA Safety Arc is an ultra-slim audible siren and panic button combo; the KATANA Safety Response Center is a subscription-based 24/7 Emergency Response Center; and the free KATANA Safety App facilitates a user’s Circle: up to seven friends and family that will be sent a map of the user’s location in the event of an emergency and more.”

6. Base


Founded: 2018

Also honored in: 2020 Best Tech Startups in South Carolina

“Base is the first-ever platform built for assistants and the executives they support, all managed in a dedicated workspace where updates from the tens of tools assistants live in daily can be organized and distributed to executives in an elegant, efficient, and reliable way.

Through our platform, assistants have access to the tools they need to spend their time on scaling high-velocity growth for businesses, putting upwards of 20% productivity back into their workweek. This increase in productivity has allowed assistants to focus on supporting their executives in more strategic ways, like providing progress to executive OKRs (Objectives and Key Results) and aligning their success to that of their executive.

We’ve seen assistants who use Base in this way future-proof their role by aligning their efforts to company revenue. In one use case, an EA influenced 12% of their organization’s annual conference revenue target.”

7. Bandwagon


Founded: 2014

Also honored in:

“Bandwagon tracks qualitative customer data for ticketed events through a proprietary blockchain database that monitors each ticket transaction. Event owners can track the economics of each ticket and stay informed of the end user who ultimately attends the event. Our core product, Stadium Identity Management Platform, is built for the sports sector, and is for pro sports organizations and college athletic departments. Stadium Identity Management helps owners identify each fan in attendance so that personalized game day experiences can be delivered.”

8. Hook Security

Hook Security

Founded: 2019

“Hook Security is a psychological and behavioral science startup designed to help companies establish policies for email and provide on-demand fake social engineering cyber attacks on employees with micro-learning and training.

Despite being a young company, Hook Security comes with experience, with founder, Adam Anderson’s immense background in cybersecurity and technology. Adam’s 15 years of entrepreneurial startup experience and his knowledge of Enterprise Cyber Defense gives him a window into what’s wrong with communication between large and small companies. Hook Security started with the goal of helping vulnerable companies from being hooked by cyber predators.

Our mission is to safeguard companies from social engineering threats in order to build an active line of defense with on-demand employee awareness training.”

9. ActivEd


Founded: 2011

“ActivEd is the ed tech company behind Walkabouts—online adventures that transform math & literacy fundamentals into standards-based, movement-rich lessons.”

10. ScopeStack


Founded: 2018

“ScopeStack is a unique presales automation tool for IT service providers. Our services CPQ platform enables engineers to increase efficiency, reduce risk, and improve service margins. Request a free trial at to see how.”