2022 Best Tech Startups in Waltham

Powered by CrunchbaseThe Tech Tribune staff has compiled the very best tech startups in Waltham, Massachusetts. In doing our research, we considered several factors including but not limited to:

  1. Revenue potential
  2. Leadership team
  3. Brand/product traction
  4. Competitive landscape

Additionally, all companies must be independent (unacquired), privately owned, at most 10 years old, and have received at least one round of funding in order to qualify.

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1. Devoted Health

Devoted Health

Founded: 2017

“Devoted Health is a new healthcare company serving seniors. Our mission is to dramatically improve the health and well-being of older Americans by caring for each and every person like they are family. We are devoted to the health and wellness of our members by helping them navigate the healthcare system with personal guides, by utilizing world-class technology to enable a simplified experience, and by partnering with top providers for better health outcomes.”

2. Infinidat


Founded: 2011

Also honored in: 2021 Best Tech Startups in Waltham

“Infinidat helps customers drive petabyte-scale competitive advantage while providing faster-than-all-flash performance, 100% availability, and the industry’s lowest total cost of ownership.”

3. TakeOff Technologies

TakeOff Technologies

Founded: 2016

Also honored in:

“Takeoff is helping grocers thrive in eCommerce.

Our automated grocery fulfillment solution was created by grocers, for grocers. It is the only eGrocery model that helps grocers not only embrace eGroceries, but thrive in an online grocery market. Together, we can lower your last-mile and assembly costs, giving you the flexibility you need to grow with your customers.”

4. Vecna Robotics

Vecna Robotics

Founded: 2018

Also honored in:

“Vecna Robotics delivers Automated Material Handling, Hybrid Fulfillment, and Workflow Optimization solutions featuring self-driving vehicles operated by our learning Autonomy Stack. Our solutions deliver value for customers in the distribution, e-commerce, warehousing, and manufacturing sectors. Our unique orchestration engine technology,, allows diverse robot types and humans to work together seamlessly and to flexibly yield an adaptive business solution, capable of meeting the increasingly unpredictable market needs.

Our technology goes beyond traditional automation and focuses on maximizing human and robot capability to create fulfilling jobs, increase productivity, and encourage innovation.”

5. Scipher Medicine

Scipher Medicine

Founded: 2014

“Scipher Medicine is building the future of patient treatment.

Most patients who are prescribed blockbuster therapies today don’t respond to the treatment, costing the health care industry billions in wasted drugs while patients continue to suffer. Scipher’s platform identifies which drug will work based on the patient’s fundamental disease biology, and not based on symptoms, disease classification, or medical bias. A simple test predicts which drug he/she will respond to, ensuring that most optimal treatment is prescribed from day one. The molecular data generated by our tests is then used to fuel novel target discovery to address a clear unmet medical need in patients who do not respond to any existing therapy.”

6. connectRN


Founded: 2014

“connectRN connects the nursing community with opportunities—and one another—to build a supportive and thriving network.”

7. InfoBionic


Founded: 2011

Also honored in:

“InfoBionic’s MoMe® Kardia system empowers physicians with control to transform the efficiency with which they manage cardiac arrhythmia detection and monitoring processes for their patients. Leveraging a comprehensive, Cloud-based remote patient monitoring platform – the first and only of its kind – we deliver on-demand, actionable monitoring data and analytics directly to the physicians themselves.

The MoMe® Kardia 3-in-1 device streams continuous ECG, respiration, and motion data to the Cloud for analysis, and delivers automated reporting to an iPad and or a web-based portal where physicians can access and interact with the data they need, in the detail they want – anytime, anywhere.”

8. Uptycs


Founded: 2016

Also honored in:

“Uptycs provides the first cloud-native security analytics platform that enables endpoint and cloud security from a single platform. The solution provides a unique telemetry-powered approach to address multiple use cases—including Extended Detection & Response (XDR), Cloud Workload Protection (CWPP), and Cloud Security Posture Management (CSPM). Uptycs enables security professionals to quickly prioritize, investigate, and respond to potential threats across a company’s entire attack surface. A free trial of Uptycs can be requested at”

9. Humatics


Founded: 2015

Also honored in:

“Humatics is pioneering microlocation technology, offering centimeter- and millimeter-scale positioning that is faster, more precise, and affordable than any existing 3D positioning or location tracking technology on the market. Our breakthrough microlocation system and analytics software comprise the Humatics Spatial Intelligence Platform™ that will revolutionize how people and machines locate, navigate and collaborate in the connected world.

Humatics was founded in 2015 by chief executive officer David Mindell (a Massachusetts Institute of Technology professor and chair of MIT’s Work of the Future Task Force) and president and chief operating officer Gary Cohen, a technology industry veteran. Headquartered in Kendall Square, Cambridge, Massachusetts, Humatics has grown to include a world-class team of radar experts, programmers, roboticists, software engineers, and product development leaders. More information is available at”

10. Linus Health

Linus Health

Founded: 2019

“We are a digital health company that seeks to leverage advances in digital biomarkers and phenotyping to revolutionize the way users—whether healthy individuals, patients, clinicians, caregivers or researchers—take ownership of their mental and brain health.”