2021 Best Tech Startups in Durham

Powered by CrunchbaseThe Tech Tribune staff has compiled the very best tech startups in Durham, North Carolina. In doing our research, we considered several factors including but not limited to:

  1. Revenue potential
  2. Leadership team
  3. Brand/product traction
  4. Competitive landscape

Additionally, all companies must be independent (unacquired), privately owned, at most 10 years old, and have received at least one round of funding in order to qualify.

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1. Baebies


Founded: 2013

Also honored in: 2020 Best Tech Startups in North Carolina

“Baebies, guided by the vision that “everyone deserves a healthy start,” delivers innovative products and services for newborn screening and pediatric testing. SEEKER® is the first newborn screening platform authorized by the U.S. FDA for lysosomal storage disorders. Still under development, FINDER™ is a small volume near-patient testing platform designed for pediatrics. FINDER™ is not available at this time for sale or use in any territory. By bringing new technologies and new tests to the healthcare community, Baebies is providing hope to parents and the chance at a better life for all children.”

2. ArchiveSocial


Founded: 2011

Also honored in:

“ArchiveSocial empowers agencies and organizations to actively participate on social networking channels by ensuring they can fulfill legal requirements and avoid lawsuits. Our cloud-based archiving and analytics technology is trusted by more than 2,000 public agencies.

Our office is located in the heart of Downtown Durham, NC, walking distance from the Durham Performing Arts Center, Durham Bulls Athletic Stadium, American Tobacco Campus, the American Underground (a Google for Entrepreneurs Tech Hub), and some of the best food in the Southeast.”

3. Get Spiffy

Get Spiffy

Founded: 2014

“Imagine your car feeling new again.

Born & raised in North Carolina’s Research Triangle Park, our team at Spiffy has always had an affinity for technology. Since 2014, we’ve used that passion to pursue our goal of truly convenient and environmentally-friendly car care for individuals and fleets across the country.

With our Spiffy app, you can schedule, track, and pay for mobile oil change, car wash, detail, and other maintenance services at a time and date that fits your schedule. Our professionally trained technicians come to you with all the equipment needed to make your car feel new again.”

4. Validic


Founded: 2010

Also honored in:

“Validic is the healthcare industry’s premier technology platform for convenient, easy access to digital health data from best-in-class clinical and remote-monitoring devices, sensors, fitness equipment, wearables and patient wellness applications. Validic’s mission is to improve the quality of human life by building technology that makes personal data actionable.

Mobile health technologies are reshaping patient engagement and population management opportunities for healthcare companies. Validic is powering this ecosystem to allow for the accelerated deployment of healthcare companies’​ strategic initiatives.”

5. Infinia ML

Infinia ML

Founded: 2017

Also honored in:

“Infinia ML applies and audits machine learning. Applications include automated document extraction, advanced document search, and text normalization. Auditing combines software and services to report on how machine learning models are working in production.

Enterprise leaders, health innovators, and government partners trust Infinia ML on critical projects with sensitive data. The company’s technical team is led by Chief Scientist Lawrence Carin, Ph.D., one of the world’s most published machine learning experts. Learn more at”

6. Hi Fidelity Genetics

Hi Fidelity Genetics

Founded: 2014

“Hi Fidelity Genetics is a computational biology company aiming to change the productivity of global agriculture.”

7. Aqueti


Founded: 2012

Also honored in:

“Aqueti builds camera array imaging systems of extreme resolution for interactive imaging applications. With significant expertise in optical design, computational imaging, computer architectures, and realtime processing we are developing next-generation imaging systems for applications ranging from drones to security to broadcast.”

8. AdWerx


Founded: 2013

Also honored in:

“Adwerx was launched in 2013 to revolutionize localized online advertising for Real Estate professionals. With a strong focus on retargeting advertisements, Adwerx is committed to helping those in the Real Estate industry utilize the technology they need to be successful and stay top-of-mind in their local markets. For as low as $40, any Real Estate agent can use this powerful tool to drive awareness for their business.”

9. Keen Decision Systems

Keen Decision Systems

Founded: 2010

Also honored in:

“Keen Decision Systems offers a software solution to help marketers make dynamic, data-driven decisions that build winning brands. Keen clients experience an average 25 percent improvement in marketing performance in the first year.

The Keen Difference:

  1. Predictive Modeling — Uses normative meta data and published academic information along with marketers’​ existing data to accurately forecast opportunity
  2. Accurate Insights — Keen generates precise forecasts across the brand portfolio to predict future financial results within about 3 percent (and machine learning improves precision over time).
  3. Expert Team — Founded by a CPG exec and a data scientist Keen brings empathy and expertise to its culture and solutions.”

10. Precision Fermentation

Precision Fermentation

Founded: 2017

“Precision Fermentation Inc. offers a groundbreaking, real-time monitoring solution that dramatically enhances control over the fermentation process for producing brewed beverages and other fermented products. Precision Fermentation’s flagship product, the BrewMonitor® System, helps ensure complete product consistency, increases manufacturing efficiency and enables greater business profitability. Together, the solution’s sensor-array device and web-based software suite continuously live-streams data from an active fermentation, offering complete fermentation process visibility and control that entirely replaces trial-and-error measurements and enables excellent product and business outcomes. For more information, visit”