2021 Best Tech Startups in Cincinnati

Powered by CrunchbaseThe Tech Tribune staff has compiled the very best tech startups in Cincinnati, Ohio. In doing our research, we considered several factors including but not limited to:

  1. Revenue potential
  2. Leadership team
  3. Brand/product traction
  4. Competitive landscape

Additionally, all companies must be independent (unacquired), privately owned, at most 10 years old, and have received at least one round of funding in order to qualify.

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1. Astronomer


Founded: 2015

Also honored in:

“Astronomer helps organizations adopt Apache Airflow®, the leading open-source data workflow orchestration platform that helps organizations get their data in motion. Backed by Sierra Ventures, Bain Capital Ventures, AngelPad, CincyTech, Refinery Ventures, Wireframe Ventures, and Frontline Ventures, Astronomer is headquartered in Cincinnati, Ohio with offices in San Francisco, New York, and London.”

2. Losant


Founded: 2015

Also honored in:

“Losant is an easy-to-use and powerful enterprise IoT platform designed to help you quickly and securely build complex real-time connected solutions. Losant uses open communication standards to provide connectivity from one to millions of devices. Losant provides powerful data collection, aggregation, and visualization features to provide you with new data insights. Losant is trusted by your development team and capable of driving business results. Start independently or if you want help to define and build your unique product, Losant’s experienced solution engineers are ready to work with you.”

3. enosiX


Founded: 2014

Also honored in:

“Delivering the perfect customer experience requires your SAP data to be accessible in real-time across your enterprise. Let our next generation of integration technology transform that experience into a competitive advantage by delivering on the promise of the intelligent enterprise.

enosix enables you to modernize your infrastructure by integrating SAP with any front-end system of engagement through an API-driven approach. Our integration solutions were created by former SAP executives with a vision for a smarter integration. The patent-pending enosix framework integrates and automates complex business processes across boundaries resulting in accelerated implementation and immediate ROI.”

4. Halo Health

Halo Health

Founded: 2010

Also honored in:

“Halo’s mission is to streamline communication, so clinicians can focus on care. The Halo Clinical Collaboration Platform enables mobile collaboration for healthcare providers by unifying secure messaging, on-call scheduling, VoIP, critical results and alerts. Halo helps health systems accelerate patient care and improve clinical and financial outcomes. Contact us for a product demo at”

5. Stack Construction Technologies

Stack Construction Technologies

Founded: 2010

Also honored in: 2020 Best Tech Startups in Cincinnati

“STACK Construction Technologies is the industry’s leading cloud-based software solution for preconstruction professionals. It provides a centralized hub where plans, specs and other construction documents can be stored, evaluated, measured and shared with internal and external project stakeholders. Founded and headquartered in Cincinnati, OH, STACK delivers intuitive and innovative software for thousands of subcontractors, general contractors, suppliers and manufacturers to ultimately improve the project’s outcome and profitability. STACK’s solution powers seamless plan and document management, real-time team collaboration and a more efficient digital takeoff and estimating process. For more information or to see how STACK software is helping preconstruction teams to gain visibility, insight and alignment throughout the bid process, visit”

6. Cordata Healthcare Innovations

Cordata Healthcare Innovations

Founded: 2014

“Cordata Healthcare Innovations, previously Priority Consult, is a healthcare solutions company that develops highly specialized software applications for more effective patient management using patient-focused, nurse navigation models. Our solutions include Cordata Spine and Cordata Oncology.”

7. Physna


Founded: 2015

Also honored in: 2020 Best Tech Startups in Cincinnati

“Physna, short for “Physical DNA”, is a revolutionary technology that compares and analyzes 3D models through shape search, quality control and more in various industries. Physna is most commonly used in engineering and CAD design, manufacturing, aerospace, defense and diverse types of inspection automation. Physna is a fast-growing software company based in downtown Cincinnati, Ohio and is a Siemens partner as well as a technology provider to NASA Space Camp, Purdue University, etc.”

8. NaviStone


Founded: 2016

“NaviStone helps advertisers turn their website visitors into direct mail customers. We have invented technology that allows our clients to connect their browsers to postal name and addresses and enable retargeting via individualized direct mail, in a privacy compliant way. NaviStone features the industry’s only double blind system, ensuring these website visitors remain anonymous both to us and the website owner. We answer the Who/What/When to send direct mail more effectively than has ever been done.

NaviStone is located in historic Over-the-Rhine, the hub of Cincinnati’s vibrant innovation culture. We exist to create an environment where team members can reach their full potential. We are curious, relentless and fearless. We pride ourselves on hiring innovative professionals who are humble, respectful, caring and fun. NaviStone was honored to be named best in “Marketing Innovation” by the Cincinnati Business Courier in 2018.”

9. tilr corporation

tilr corporation

Founded: 2015

Also honored in:

“tilr is advancing the way companies recruit. tilr is an automated hiring solution for the recruitment process. Our algorithm matches job seekers to jobs based on skills and geographical location. tilr allows workers to find jobs they’re qualified for, near them.

By emphasizing skills over job titles, tilr gives companies access to a growing, qualified worker pool. This means an improved hiring process for companies and new opportunities for workers.

Our mission is to create a seamless connection between job seekers and hiring managers, eliminating the need for the resume and allowing people to find meaningful work.”

10. Polar 3D

Polar 3D

Founded: 2013

Also honored in:

“The Polar Cloud makes 3D printing universally accessible by giving anyone with a browser the ability to create and transform digital models into physical objects.

It’s about educating and enabling a future for digital manufacturing by building the Polar Cloud into the largest 3D printing & making ecosystem in the world.

Efficiently manage unlimited 3D printers, students, files and curriculum from a single platform that provides complete visibility and control to drive access, engagement and better student outcomes.”

11. Enable Injections

Enable Injections

Founded: 2011

“Cincinnati-based Enable Injections is a healthcare technology innovator and startup developing and manufacturing large-volume wearable drug delivery systems – aiming to transform patient access to care by supporting flexible delivery, superior patient experience, and improved healthcare system value and economics.

Once approved by regulatory authorities, Enable’s wearable enFuse® drug delivery platform enables AnywhereCare TM – large-volume therapeutic delivery via subcutaneous administration in a healthcare clinic, with a healthcare professional at a patient’s home, or via self-administration at home.

Enable’s enFuse® utilizes standard container closure systems to deliver large volumes up to 50 mL of high-viscosity pharmaceutical and biopharmaceutical therapeutics. For more information, visit us at”