2022 Best Tech Startups in Durham

Powered by CrunchbaseThe Tech Tribune staff has compiled the very best tech startups in Durham, North Carolina. In doing our research, we considered several factors including but not limited to:

  1. Revenue potential
  2. Leadership team
  3. Brand/product traction
  4. Competitive landscape

Additionally, all companies must be independent (unacquired), privately owned, at most 10 years old, and have received at least one round of funding in order to qualify.

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1. FlexGen


Founded: 2014

“FlexGen is a leading energy storage technology solutions and services provider that delivers advisory, product technology and operational maintenance services. Formed in 2015, FlexGen offers proven energy storage technology solutions designed to manage the diverse challenges of industrial and utility customers worldwide.”

2. Pairwise Plants LLC

Pairwise Plants LLC

Founded: 2017

Also honored in: 2021 Best Tech Startups in North Carolina

“Pairwise is a start-up food company that uses technology to break down the barriers that keep us from eating produce. We are passionate about reducing diet-based disease by driving an increase in the consumption of fruits and vegetables.

Headquartered in Durham, NC, our team is made up of leaders in R&D, agriculture, and consumer products. Founded in 2017 and opened in 2018, Pairwise is working to deliver breakthrough innovation in agricultural sciences and in healthy consumer foods.

Our team of proven leaders features Dr. Tom Adams, Chief Executive Officer (CEO), Dr. Haven Baker, Chief Business Officer (CBO), and preeminent scientists Drs. Feng Zhang, David Liu and J. Keith Joung serve as advisors.”

3. Baebies


Founded: 2013

Also honored in:

“Baebies, guided by the vision that “everyone deserves a healthy start,” delivers innovative products and services for newborn screening and pediatric testing. SEEKER® is the first newborn screening platform authorized by the U.S. FDA for lysosomal storage disorders. Still under development, FINDER™ is a small volume near-patient testing platform designed for pediatrics. FINDER™ is not available at this time for sale or use in any territory. By bringing new technologies and new tests to the healthcare community, Baebies is providing hope to parents and the chance at a better life for all children.”

4. ArchiveSocial


Founded: 2011

Also honored in:

“ArchiveSocial empowers agencies and organizations to actively participate on social networking channels by ensuring they can fulfill legal requirements and avoid lawsuits. Our cloud-based archiving and analytics technology is trusted by more than 2,000 public agencies.

Our office is located in the heart of Downtown Durham, NC, walking distance from the Durham Performing Arts Center, Durham Bulls Athletic Stadium, American Tobacco Campus, the American Underground (a Google for Entrepreneurs Tech Hub), and some of the best food in the Southeast.”

5. ServiceTrade


Founded: 2012

Also honored in:

“ServiceTrade helps commercial service companies deliver an amazing customer experience and increase the value of their business.

ServiceTrade is a software as a service platform that manages job scheduling, technician scheduling and efficient routing for single or multiple offices in an easy user interface. Documentation of the work performed is stored online and delivered to customers’ inboxes for always-on access to service history. Online communication and coordination between field technicians, the home office, and the customer make each appointment more professional.”

6. Get Spiffy

Get Spiffy

Founded: 2014

Also honored in:

“Imagine your car feeling new again.

Born & raised in North Carolina’s Research Triangle Park, our team at Spiffy has always had an affinity for technology. Since 2014, we’ve used that passion to pursue our goal of truly convenient and environmentally-friendly car care for individuals and fleets across the country.

With our Spiffy app, you can schedule, track, and pay for mobile oil change, car wash, detail, and other maintenance services at a time and date that fits your schedule. Our professionally trained technicians come to you with all the equipment needed to make your car feel new again.”

7. Higharc


Founded: 2018

“Higharc is the all-in-one platform for home building that simplifies, connects and improves each step of the design, construction and sales process.

Higharc is VC-backed and is led by a founding team who’ve launched products for Autodesk, EA, Nike, and Apple. We’re looking for world-class engineers and designers.”

8. Restor3d


Founded: 2017

“restor3d enables surgeons to improve the reconstruction and repair of the human body through 3D printed implants with enhanced anatomical fit and superior integrative properties. Leveraging expertise and experience in 3D printing of key biomedical materials spanning a wide range of properties, restor3d seeks to improve medical device solutions.”

9. Matchwell


Founded: 2017

“Matchwell is a tech company that matches healthcare organizations and schools with care staff, nurses and therapists.

They directly communicate where and when work happens. No middleman. Only a simple, fully transparent, cost-saving approach that has transformed the flexible work world.

The future of healthcare work is finally here.”

10. Infinia ML

Infinia ML

Founded: 2017

Also honored in:

“Infinia ML applies and audits machine learning. Applications include automated document extraction, advanced document search, and text normalization. Auditing combines software and services to report on how machine learning models are working in production.

Enterprise leaders, health innovators, and government partners trust Infinia ML on critical projects with sensitive data. The company’s technical team is led by Chief Scientist Lawrence Carin, Ph.D., one of the world’s most published machine learning experts. Learn more at”