2022 Best Tech Startups in Indianapolis

Powered by CrunchbaseThe Tech Tribune staff has compiled the very best tech startups in Indianapolis, Indiana. In doing our research, we considered several factors including but not limited to:

  1. Revenue potential
  2. Leadership team
  3. Brand/product traction
  4. Competitive landscape

Additionally, all companies must be independent (unacquired), privately owned, at most 10 years old, and have received at least one round of funding in order to qualify.

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1. Greenlight Guru

Greenlight Guru

Founded: 2013

“Greenlight Guru is a modern quality management software platform built exclusively for the unique needs of the medical device industry.

Our platform is currently being used by innovative medical device companies in over 600 cities and 50 countries on 6 continents to bring new products to market faster while simplifying regulatory compliance and reducing risk.

Device makers across the globe are replacing their outdated paper-based and general purpose legacy quality systems with Greenlight Guru.”

2. hc1


Founded: 2011

Also honored in:

“Founded to improve lives with high-value care, hc1 has emerged as the bioinformatics leader in precision testing and prescribing. The cloud-based hc1 Platform organizes live data, including lab results, genomics, and medications, to deliver solutions that ensure the right patient gets the right test and the right prescription. Today, the hc1 Platform powers two flagship solutions hc1 Lab CRM and hc1 Test Utilization™, as well as breakthrough precision prescribing innovations hc1 Opioid Advisor™ and hc1 PGx Advisor™. To learn more about hc1’s proven approach to personalizing care while eliminating waste for thousands of health systems, diagnostic laboratories, and health plans, visit and follow us on Twitter, Facebook, and LinkedIn.”

3. Sharpen Technologies

Sharpen Technologies

Founded: 2011

Also honored in:

“Sharpen is a cloud-native contact center platform that helps companies create perfect customer experiences.

Our contact center software is ideal for mid-size to enterprise businesses. Designed for agent productivity and efficiency, it’s the perfect solution for both customer support to outbound sales teams.”

4. Zylo


Founded: 2015

Also honored in:

“SaaS changed the way software is purchased. Zylo is the leading SaaS optimization platform changing the way software is managed with over $1 billion of Cloud subscriptions under management. By combining SaaS application spend, utilization, and feedback data, our SaaS management tool helps enterprises discover, manage, measure and optimize their SaaS investments.”

5. Bloomerang


Founded: 2012

Also honored in: 2021 Best Tech Startups in Indiana

“Bloomerang helps nonprofit organizations to reach, engage and retain the advocates they depend on to achieve their vision for a better world. Our cloud-based donor management application is rooted in principles of philanthropy, simple to use and focused on empowering your team to achieve remarkable results through enhanced donor loyalty.

We have pooled together the latest in best practices for fundraising, loyalty, engagement, and retention to create a simple donor database solution that helps nonprofits decrease donor attrition and increase revenue.

Plugging in the latest technologies and delivering them with a clean, modern interface and with the added benefit of donor retention insights, our system is your “go-to” for better fundraising!”

6. Springbuk


Founded: 2015

Also honored in:

“Based in Indianapolis, Indiana, Springbuk is a health analytics software solution. The company’s health intelligence platform unifies medical claims, pharmacy, biometric and activity data. The predictive modeling engine helps employers target their engagement with pinpoint accuracy, forecast overall healthcare spending, identify at-risk employees, and measure their wellness programs.”

7. Kerauno


Founded: 2018

Also honored in:

“Kerauno is a leading provider of global cloud communications solutions for business around the world.

Our solutions focus on advancing communication interactions by breaking down the technology barriers between people, process and systems through the use of powerfully intuitive experiences, deeper engagements and greater intelligence. We deliver an extensive range of unique business offerings, including: Kerauno UCaaS –Unified Communications, collaboration and contact center; Kerauno Launch – Text engagement platform; Next Gen –Communications orchestration platform; Inverse-Square – Custom development.”

8. MetaCX


Founded: 2018

Also honored in: 

“MetaCX, a new High Alpha Studio company, has raised over $14 million in early funding to transform how businesses manage their customers and how customers manage their vendors. The funding was led by Upfront Ventures, a leading early-stage venture capital firm based in Los Angeles.

The company is led by Co-Founder and CEO Scott McCorkle, a globally-recognized technology leader who joined High Alpha as Executive in Residence in early 2017. He most recently served as CEO of Salesforce Marketing Cloud and previously served as President of ExactTarget prior to its acquisition by Salesforce.”

9. Encamp


Founded: 2017

“Encamp is the environmental compliance management and reporting platform for today’s EHS professionals. Our solutions enable companies to proactively manage risk by aggregating and centralizing critical compliance data, streamlining workflows, and automating the submission of regulatory reports and filings as well as required reporting and registration fees where applicable.”

10. Mandolin


Founded: 2020

“Mandolin is a digital platform designed to help artists, venues, and fans connect through live music. We’re on a journey to redefine live entertainment and bring live music back to the stage, whether we’re in the same room or across the globe.”