2025 Best Tech Startups in Indiana

March 27, 2025 thetechtribune

The Tech Tribune staff has compiled the very best tech startups in Indiana. In doing our research, we considered several factors including but not limited to:

Revenue potential
Leadership team
Brand/product traction
Competitive landscape

Additionally, all companies must be independent (unacquired), privately owned, at most 10 years old, and have received at least one round of funding in order to qualify.

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10. SalesAi

Founded: 2019

“Automate Your Revenue Engine with SalesAi – the ultimate solution for initiating, and engaging high quality leads while scheduling meetings seamlessly.

Create high-quality interactions with your top prospects where Ai-driven automation optimizes lead qualification, routing, and engagement to boost efficiency and skyrocket conversion rates.

Remove Human Error and Increase Efficiency by 5x – Create high-quality interactions with your top prospects where Ai-driven automation optimizes lead qualification, routing, and engagement to boost efficiency and skyrocket conversion rates.”

9. Springbuk

Founded: 2015

Also honored in:

“Imagine a world where every healthcare and benefits program decision is backed and guided by data. Springbuk is the health data analytics solution that equips you with the insights and expertise you need to sharpen your benefits strategy, advance employee health, and contain costs. Unlike legacy data warehouses, we simplify data-driven decision-making with an intuitive user experience, predictive modeling, and curated action steps. Springbuk — a world of actionable health intelligence insight, at your fingertips. Visit springbuk.com to learn more.”

8. Encamp

Founded: 2017

Also honored in:

“Encamp is an enterprise technology company on a mission to create a world in which what’s good for business can be good for the environment. Since launching in 2017, Encamp has helped top organizations radically improve their environmental compliance operations and mitigate the risks of non-compliance. By utilizing a blended method of high-tech solutions, along with high-touch expert support, Encamp transforms compliance programs and human processes into a technology-driven system that lays the foundation for accurate and ongoing environmental compliance. A portion of Encamp’s revenue is allocated to plant trees across the world, helping sequester carbon and promote human and environmental health for those that need it the most.”

7. BiomEdit

Founded: 2022

Also honored in: 2024 Best Tech Startups in Indiana

“BiomEdit is an innovation company that discovers, designs, and develops novel probiotics, microbiome derived bioactives, and engineered microbial medicines to address unmet needs in animal health. Our ambition is to create solutions to some of the most important problems in animal agriculture and food security by leveraging the potential of the microbiome.

BiomEdit’s technology is based on a unique platform that utilizes high-throughput sequencing and data analytics to rapidly discover and screen novel probiotic species and bioactive molecules. These can then be engineered to confer thermostability, enhanced production of beneficial metabolites, or expression of immune modulating proteins. These probiotics and microbially-derived compounds represent the next generation of products designed to promote animal health without the use of antibiotics.”

6. 120Water

Founded: 2016

Also honored in: 2024 Best Tech Startups in Indiana

“120Water is the fastest growing digital water company in the country. Our platform is a turnkey solution that makes drinking water program management and compliance simple.

Our mission is to transform the water industry by enabling government agencies, public water systems, and facilities to easily manage their drinking water or wastewater programs.”

5. Zylo

Founded: 2015

Also honored in:

“As the leader in enterprise SaaS Management and Optimization, Zylo enables companies to organize, optimize, and orchestrate SaaS. Organizations such as Adobe, Atlassian, Coupa, Hootsuite, Intuit, Slack, Salesforce, and Verizon Media leverage Zylo’s enterprise-proven technology and unparalleled SaaS Management expertise to control the rising costs and risks of SaaS while improving the software experience for employees.

Zylo’s patent-pending, AI-powered Discovery Engine provides continual, frictionless monitoring of SaaS spend, licenses, and usage to create the industry’s most accurate SaaS system of record. With more than 34 million SaaS licenses and $30 billion in SaaS spend under management, Zylo is fueled by more data than any other provider, and delivers actionable insights and automated workflows that enable IT and Finance teams to effectively and efficiently manage and optimize their growing SaaS portfolios. To learn more, visit zylo.com.”

4. Taranis

Founded: 2014

Also honored in:

“Taranis is a leading precision agriculture intelligence platform that uses sophisticated computer vision, data science and deep learning algorithms to effectively monitor fields. Taranis offers a full-stack solution for high precision aerial surveillance imagery to prevent crop yield loss due to insects, crop Farmers lose 30-40% of their yield every season due to crop diseases, insects, and weeds. Our mission: Help growers maximize crop yield, improve productivity, and adopt sustainable practices in order to ensure prosperity, starting in our local communities and for the benefit of the world.

Taranis crop intelligence solutions use deep agronomic expertise and the most advanced AI and submillimeter image technologies to do just that. We make an impact for over 100 agribusinesses, thousands of farmers, and in millions of acres around the world, and grow rapidly.”

3. Remodel Health

Founded: 2015

“Remodel Health is the expert guide for employers and brokers navigating the complexities of transitioning to ICHRA (Individual Coverage Health Reimbursement Arrangement). With nearly a decade of experience in the individual health benefits space, our proprietary software and licensed health benefits experts deliver tailored solutions for businesses with 100 to 10,000 employees. Committed to best-in-class customer service, we provide hands-on support throughout the process, ensuring successful implementation and long-term success. Learn more about how we transform health benefits at remodelhealth.com.”

2. Sanctuary Wealth

Founded: 2018

Also honored in: 2024 Best Tech Startups in Indiana

“Sanctuary Wealth (sanctuarywealth.com/) is the advanced platform for the next generation of elite advisors, who have the entrepreneurial spirit to build and own their own practices and desire the freedom to deliver the tailored service their clients deserve. Sanctuary’s ecosystem of partnered independence provides a complete technology and operations platform, as well as support from a community of like-minded advisors and the resources of invaluable affiliated businesses.

Currently, the Sanctuary Wealth network includes partner firms across 20 states with over $16.0 billion in assets under advisement. The Sanctuary Wealth Group includes the fully owned subsidiaries Sanctuary Advisors, a registered investment adviser, and the broker-dealer Sanctuary Securities, as well as Sanctuary Alternative Solutions, Sanctuary Insurance Solutions, Sanctuary Global, and Sanctuary Global Tax and Family Office.”

1. StarPlus Energy

Founded: 2022

“StarPlus Energy, the new startup venture from Samsung SDI and Stellantis, is building their first electric vehicle battery manufacturing plant of North America in Kokomo, Indiana.”