2022 Best Tech Startups in St. Louis

Powered by CrunchbaseThe Tech Tribune staff has compiled the very best tech startups in St. Louis, Missouri. In doing our research, we considered several factors including but not limited to:

  1. Revenue potential
  2. Leadership team
  3. Brand/product traction
  4. Competitive landscape

Additionally, all companies must be independent (unacquired), privately owned, at most 10 years old, and have received at least one round of funding in order to qualify.

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1. MediBeacon


Founded: 2011

Also honored in:

“MediBeacon creates novel light-activated agents to enable medical innovations. A noninvasive real-time kidney function monitoring system is in human clinical trials.”

2. SteadyMD


Founded: 2016

Also honored in:

“SteadyMD is a technology company and healthcare provider that delivers high-quality telehealth experiences for consumers, employers, digital health companies, and clinicians.

For consumers and employers, the company offers online Primary Care, Functional Medicine, and Pediatric Care.

For digital health companies, the company provides an on-demand physician workforce, legal and regulatory guidance, and customized technology.

For clinicians, the company offers a variety of telehealth opportunities, from online urgent care to online concierge medicine.”

3. SentiAR


Founded: 2017

Also honored in: 2021 Best Tech Startups in St. Louis

“The Reality of Safe and Simple.

SentiAR is digital health, software device company adding a new dimension to clinical practice in interventional procedures. Spun out of Washington University, we are developing the first 3D visualization platform using real time holography of the patient’s anatomy and catheter location, “floating”​ over the patients, with a goal to provide the clinician and patient a faster, safer delivery of care.”

4. Balto


Founded: 2017

Also honored in: 2020 Best Tech Startups in St. Louis

“Increase conversions, deliver a world-class customer experience, and decrease ramp time with Balto’s Real-Time Guidance for contact centers.

Balto is the #1 Real-Time Guidance for contact centers. Powered by AI, Balto listens to both sides of a conversation and visually prompts agents with the best things to say, live on every call. Scale “perfect” to thousands of agents with the push of a button and get immediate insight into what’s working and what’s not.

Learn more about the #1 Real-Time Guidance platform at”

5. Bonfyre


Founded: 2012

Also honored in:

“Bonfyre is a workplace culture platform for building human connections in a modern, more remote workforce. We do this by giving employees the digital space – separate from productivity tools – they need to recreate the casual “water cooler” interactions that build relationships, trust and inclusion. Our platform is an everyday, frontend destination for culture drivers such as team building, recognition, surveys, employee wellbeing, philanthropy, communities of shared interest, and more. And with everything in one place, we identify and suggest the specific actions employees can take – from sharing a photo to recognizing a colleague – to improve business outcomes like retention, satisfaction and performance.”

6. Adalo


Founded: 2018

“We believe anyone one should be able to make an app, regardless of technical skill. Adalo is a platform that makes creating apps as easy as putting together a slide deck.

Creating web and mobile apps traditionally required learning how to code, finding a technical cofounder, or raising a lot of capital. For some, this means spending lots of precious time and money before they can get their idea off the ground. For others, this cost is simply too high and they walk away from their dream.

With Adalo, anyone can turn their idea into a real app — without having to hire expensive developers.”

7. CareSignal


Founded: 2016

Also honored in: 2021 Best Tech Startups in St. Louis

“CareSignal’s Deviceless Remote Patient Monitoring helps value-based care entities manage rising-risk patients to improve clinical and financial outcomes. Our highly scalable, automated platform collects patient-reported health data to identify rising-risk patients before they worsen, enabling care teams to prevent costly hospitalizations or exacerbations. With 10+ peer-reviewed publications and 27 chronic and behavioral health conditions supported, we deliver a highly scalable, evidence-based platform that is aligned with quality metrics to meet your organizations evolving business goals.”

8. NOUS Imaging

NOUS Imaging

Founded: 2017

“NOUS Imaging is a transformational medical imaging software company developing unique solutions in the MR space. Future applications are poised to revolutionize the way MR images are acquired and utilized in both adult and pediatric populations. The NOUS mission is to deliver cost-effective imaging enhancements, establish next generation data analytics, and create a new patient centric experience in the MR suite.”

9. Denim Social

Denim Social

Founded: 2015

Also honored in: 

“Denim Social is a social media management software company that provides tools to empower marketers in regulated industries to manage organic social media content and paid social media advertising on one platform. Trusted by more than 250 institutions in banking, insurance, mortgage and wealth management, Denim Social enables brands to engage consumers on social media, deepen relationships with communities and close more deals while staying in compliance. Denim Social is the only ABA-endorsed social media management platform for banks and financial services firms. Learn more at”

10. Textel


Founded: 2014

“Textel provides a cloud-based texting platform for contact centers specifically designed to dramatically improve the customer experience, increase customer engagement, and improve contact center performance and efficiency.

With nearly 800 customers across North America, Textel enables inbound/outbound SMS and MMS texts for contact centers who need to connect with customers faster and more efficiently than traditional channels (email, voice, chat). Best of all, Textel users can enable their pre-existing numbers and integrate with industry-leading CCaaS solutions (Genesys, NICE inContact, and more).”