2025 Best Tech Startups in Pennsylvania

January 25, 2025 thetechtribune

The Tech Tribune staff has compiled the very best tech startups in Pennsylvania. In doing our research, we considered several factors including but not limited to:

Revenue potential
Leadership team
Brand/product traction
Competitive landscape

Additionally, all companies must be independent (unacquired), privately owned, at most 10 years old, and have received at least one round of funding in order to qualify.

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10. LIO Insurance

Founded: 2020

“LIO is a specialty insurance carrier that combines years of in-house underwriting and claims expertise with a commitment to technological innovation and exceptional customer service.

Rated A- VIII (Excellent) by AM Best and unburdened by legacy liabilities, LIO delivers a streamlined experience, including bindable quotes in minutes via its next-generation digital portal, flexible submission options, a 24/7 online claims portal, and an industry-leading NPS score of 78.4.”

9. Cornelis Networks

Founded: 2019

“Cornelis is a leading provider of end-to-end purpose-built high-performance fabrics to commercial, scientific, academic, and government organizations, delivering optimal performance, scalability, and efficiency across hyperscale, cloud AI, and on-premises AI/HPC environments. Our offerings address key requirements essential for modern AI infrastructure, including scalable architecture, high bandwidth solutions, and universal compatibility with accelerators and GPUs.”

9. ZeroEyes

Founded: 2018

“ZeroEyes is the industry’s leading AI-based weapons detection solution. Our software integrates into existing security and surveillance camera systems and sends out a series of alerts when a verified gun is detected via our best-in-class weapons detection algorithms. The ZeroEyes platform is the most proactive and actionable early-warning system on the market, allowing users to “Save time, save lives”.

Founded by former US Military veterans with deep special operations and intelligence community experience, ZeroEyes is the trusted weapons detection provider of numerous clients, to include the US Department of Defense, leading public K-12 school districts, commercial property groups, Fortune 1000 corporate campuses, supply chain and distribution facilities, shopping malls, and big box retail.

The company is headquartered in Conshohocken, PA and has additional offices in Alexandria, VA and Hawaii.”

8. Mobilion Systems

Founded: 2015

Also honored in:

“MOBILion’s technology makes it easy to separate, identify and analyze the most challenging molecules that other instruments fail to detect. Our higher resolution, faster analysis and simpler workflows reveal molecules that are most important in characterizing biologic therapeutics, discovering biomarkers, and improving the accuracy of diagnostic tests. We make today’s treatment’s safer and more effective, empower tomorrow’s disease prediction and diagnosis, and accelerate the development of new therapies.”

7. Crossbeam

Founded: 2018

Also honored in:

“Crossbeam is the first and largest Ecosystem-Led Growth platform, used by over 30,000 companies to attract, convert, and grow customer relationships using their partner ecosystems. Ecosystem is Everything.”

5. Tendo

Founded: 2020

Also honored in:

“It’s time to reimagine what’s possible in healthcare.

At Tendo, we’re on a mission to become the trusted connection between patients, clinicians, and caregivers by creating software that provides seamless, intelligent, and user-friendly experiences throughout the care journey.”

4. Abridge

Founded: 2018

Also honored in: 2023 Best Tech Startups in Pittsburgh

“Abridge was founded in 2018 with the mission of powering deeper understanding in healthcare. Our AI-powered platform was purpose-built for medical conversations, improving clinical documentation efficiencies while enabling clinicians to focus on what matters most—their patients.

Our enterprise-grade technology transforms patient-clinician conversations into structured clinical notes in real-time, with deep EMR integrations. Powered by Linked Evidence and our purpose-built, auditable AI, we are the only company that maps AI-generated summaries to ground truth, helping providers quickly trust and verify the output. As pioneers in generative AI for healthcare, we are setting the industry standards for the responsible deployment of AI across health systems.”

3. Skild AI

Founded: 2023

“Building general purpose robotic intelligence.”

2. dbt Labs

Founded: 2016

Also honored in:

“dbt Labs is on a mission to empower data practitioners to create and disseminate organizational knowledge. Since pioneering the practice of analytics engineering through the creation of dbt—the data transformation framework made for anyone that knows SQL—we’ve been fortunate to watch more than 20,000 companies use dbt to build faster and more reliable analytics workflows.

dbt Labs also supports more than 3,000 customers using dbt Cloud, the centralized development experience for analysts and engineers alike to safely deploy, monitor, and investigate that code—all in one web-based UI.”

1. Everest Infrastructure Partners

Founded: 2015

Also honored in:

“Everest Infrastructure Partners owns and markets thousands of wireless infrastructure locations that help connect today’s rapidly evolving communications networks. We are a team of industry veterans with expertise in delivering mission-critical infrastructure solutions to hundreds of network operator customers. We are one of the largest tower companies in the U.S., and we are excited to help support the incredible potential of emerging technologies in the next generation of wireless networks.

Everest currently markets more than 4,000 locations with vertical real estate available to network providers.”

2 thoughts on “2025 Best Tech Startups in Pennsylvania”

Sean Stites

February 13, 2021 at 8:10 am

This is a great resource for Investors that seek to infuse capital into the best Keystone private tech companies. Keep us posted.
Funding Metrics

June 9, 2023 at 5:10 pm

Thanks for sharing and featuring Funding Metrics!